Tumor, Temprature and Thermal Effects of Photodynamic Therapy

Effects of Combined Sonodynamic and Photodynamic Therapies on a Colon Carcinoma Tumor Model

Objective(s)   Although photodynamic therapy is considered as a noninvasive method, most photosensitizers are susceptible to  ultrasound.  Therefore,  it  is  expected  that  the  combination of  two  activation  methods  might  have  a synergistic effect. This probable effect has been investigated in this study.   Materials and Methods   This  study  was  conducted  on  colon  carcinoma ...

Photodynamic therapy and anti-tumor immunity.

BACKGROUND AND OBJECTIVES Photodynamic therapy (PDT) efficacy appears to be enhanced in the presence of an intact immune system and PDT has been shown to augment anti-tumor immunity. The mechanisms leading to the enhancement of the host immune response to tumor are unclear. Anti-tumor immunity depends upon the presence of activated antigen presenting cells (APCs). These cells are activated by t...

Direct tumor damage mechanisms of photodynamic therapy.

Photodynamic therapy (PDT) is a clinically approved and rapidly developing cancer treatment regimen. It is a minimally invasive two-stage procedure that requires administration of a photosensitizing agent followed by illumination of the tumor with visible light usually generated by laser sources. A third component of PDT is molecular oxygen which is required for the most effective antitumor eff...

Determination of Vascular Endothelial- and Fibroblast-Growth Factor Receptors in a Mouse Fibrosarcoma Tumor Model Following Photodynamic Therapy

The role of angiogenic molecules, like vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) in tumor angiogenesis was well confirmed. Photodynamic therapy (PDT) action is, to very high degree, based on tumor vasculature damage. Therefore, it seemed to be important to evaluate growth factor receptors after PDT. The extent of receptor expression was studied by immuno-histo...

Photodynamic Therapy to Eradicate Tumor Cells